In polyglutamine diseases, accumulation in the nucleus of mutant proteins induces the formation of neuronal intranuclear inclusions (NIIs).The nucleus is compartmentalized into structural and functional domains, which are involved in NII formation.Promyelocytic leukemia protein (PML), a major component of nuclear bodies, and mSin3A, a component of
Abstract Background Tumor recurrence and mortality rates remain challenging in cancer patients despite comprehensive treatment.Neoadjuvant chemotherapy and immunotherapy aim to eliminate residual tumor cells, reducing the risk of recurrence.However, drug resistance during neoadjuvant therapy is a significant hurdle.Recent studies suggest a correlat
Metal mineral resources are critical materials for the world economic development.In a situation of weak supply of terrestrial rare metals, many countries are expanding the direction of resource extraction from a land-based approach to a land-sea approach, with an increased emphasis on marine resource extraction.Aiming at the problem of efficient e